BACKGROUND: The incidence of iron deficiency anaemia in infants, which is caused by the increased iron demand for rapid growth during this period, is reported to range from 10 to 40%. This age group also suffers from a number of acute illnesses (urinary tract infection, pneumonia and other viral illness). The aim of this study was to evaluate the usefulness of soluble transferrin receptor (sTfR) values and the different methods of calculating the sTfR and serum ferritin (SF) ratio for differentiating anemia of inflammation (AI) from iron deficiency anemia (IDA) or a mixture of these two types of anemia.
METHODS: 173 infants among all the infants who visited Gyeongsang National University Hospital from 2000 to 2006 were enrolled in this study. The hemoglobin (Hb), SF and sTfR values were checked and the infants were divided into the Al subgroup (Hb <11g/dL and SF > 50microgram/L), the IDA subgroup (Hb <11g/dL and SF < 12microgram/L), the normal group (Hb > or =11g/dL and SF > or =12microgram/L), and the unclassified anemia (UCA) group (Hb <11g/dL and SF 12~50microgram/L).
RESULTS: The mean sTfR and sTfR/Log SF values in the AI group were 3.89 and 10.6microgram/mL, respectively (P<0.01). These values in the IDA group were 1.9 and 36.11, respectively (P<0.01). The mean Log (sTfR/SF) was statistically significant between all the subgroups (1.35 in AI, 3.29 in IDA, 1.76 in Nor and 2.35 in UCA). All the infants in the IDA group had a Log (sTfR/SF) value >2.55 whereas all the infants classified in AI group had a Log (sTfR/SF) value <2.55.
CONCLUSION: The Log (sTfR/SF) value is a useful criterion for discriminating between AI and IDA.
Friday
Thursday
The Usefulness of the Serum Transferrin Receptor to Serum Ferritin Ratio for Discriminating between Iron Deficiency Anemia and Anemin of Inflamation
BACKGROUND:
The incidence of iron deficiency anaemia in infants, which is caused by the increased iron demand for rapid growth during this period, is reported to range from 10 to 40%. This age group also suffers from a number of acute illnesses (urinary tract infection, pneumonia and other viral illness). The aim of this study was to evaluate the usefulness of soluble transferrin receptor (sTfR) values and the different methods of calculating the sTfR and serum ferritin (SF) ratio for differentiating anemia of inflammation (AI) from iron deficiency anemia (IDA) or a mixture of these two types of anemia.
METHODS:
173 infants among all the infants who visited Gyeongsang National University Hospital from 2000 to 2006 were enrolled in this study. The hemoglobin (Hb), SF and sTfR values were checked and the infants were divided into the Al subgroup (Hb <11g/dL and SF > 50microgram/L), the IDA subgroup (Hb <11g/dL and SF < 12microgram/L), the normal group (Hb > or =11g/dL and SF > or =12microgram/L), and the unclassified anemia (UCA) group (Hb <11g/dL and SF 12~50microgram/L).
RESULTS:
The mean sTfR and sTfR/Log SF values in the AI group were 3.89 and 10.6 microgram/mL, respectively (P<0.01). These values in the IDA group were 1.9 and 36.11, respectively (P<0.01). The mean Log (sTfR/SF) was statistically significant between all the subgroups (1.35 in AI, 3.29 in IDA, 1.76 in Nor and 2.35 in UCA). All the infants in the IDA group had a Log (sTfR/SF) value >2.55 whereas all the infants classified in AI group had a Log (sTfR/SF) value <2.55.
CONCLUSION:
The Log (sTfR/SF) value is a useful criterion for discriminating between AI and IDA.
The incidence of iron deficiency anaemia in infants, which is caused by the increased iron demand for rapid growth during this period, is reported to range from 10 to 40%. This age group also suffers from a number of acute illnesses (urinary tract infection, pneumonia and other viral illness). The aim of this study was to evaluate the usefulness of soluble transferrin receptor (sTfR) values and the different methods of calculating the sTfR and serum ferritin (SF) ratio for differentiating anemia of inflammation (AI) from iron deficiency anemia (IDA) or a mixture of these two types of anemia.
METHODS:
173 infants among all the infants who visited Gyeongsang National University Hospital from 2000 to 2006 were enrolled in this study. The hemoglobin (Hb), SF and sTfR values were checked and the infants were divided into the Al subgroup (Hb <11g/dL and SF > 50microgram/L), the IDA subgroup (Hb <11g/dL and SF < 12microgram/L), the normal group (Hb > or =11g/dL and SF > or =12microgram/L), and the unclassified anemia (UCA) group (Hb <11g/dL and SF 12~50microgram/L).
RESULTS:
The mean sTfR and sTfR/Log SF values in the AI group were 3.89 and 10.6 microgram/mL, respectively (P<0.01). These values in the IDA group were 1.9 and 36.11, respectively (P<0.01). The mean Log (sTfR/SF) was statistically significant between all the subgroups (1.35 in AI, 3.29 in IDA, 1.76 in Nor and 2.35 in UCA). All the infants in the IDA group had a Log (sTfR/SF) value >2.55 whereas all the infants classified in AI group had a Log (sTfR/SF) value <2.55.
CONCLUSION:
The Log (sTfR/SF) value is a useful criterion for discriminating between AI and IDA.
Tuesday
Taking iron measures - Human Transferrin
A more accurate method to measure iron in clinical samples is proving ahead of its time, say researchers in Spain.
The group at the University of Oviedo in Spain, led by Alfredo Sanz-Medel, has developed a technique that allows many variables that can indicate iron-related disease to be measured simultaneously and with great precision.
"Iron is used in numerous enzymes and processes throughout the human body"Any imbalance in the amount of iron in the body can lead to disease, said Sanz-Medel. But many different parameters need to be measured to detect such pathologies - since the metal is used not just as an oxygen transporter in the blood but also in numerous enzymes and processes throughout the human body. Until now these parameters have had to be measured separately, often needing multiple steps.
Sanz-Medel's method avoids this and uses transferrin (Tf), a blood plasma protein that transports iron around the body, to measure iron levels in serum. The group saturate the transferrin with either naturally-occurring iron or a non-radioactive isotope and use high performance liquid chromatography (HPLC) and inductively coupled plasma-mass spectrometry (ICP-MS) techniques to measure the amounts of the metal and protein. By comparing the iron isotope ratios, the data can be used to extrapolate clinically useful parameters including the amount of iron bound to tranferrin (Tf) and unbound in serum.
The group at the University of Oviedo in Spain, led by Alfredo Sanz-Medel, has developed a technique that allows many variables that can indicate iron-related disease to be measured simultaneously and with great precision.
"Iron is used in numerous enzymes and processes throughout the human body"Any imbalance in the amount of iron in the body can lead to disease, said Sanz-Medel. But many different parameters need to be measured to detect such pathologies - since the metal is used not just as an oxygen transporter in the blood but also in numerous enzymes and processes throughout the human body. Until now these parameters have had to be measured separately, often needing multiple steps.
Sanz-Medel's method avoids this and uses transferrin (Tf), a blood plasma protein that transports iron around the body, to measure iron levels in serum. The group saturate the transferrin with either naturally-occurring iron or a non-radioactive isotope and use high performance liquid chromatography (HPLC) and inductively coupled plasma-mass spectrometry (ICP-MS) techniques to measure the amounts of the metal and protein. By comparing the iron isotope ratios, the data can be used to extrapolate clinically useful parameters including the amount of iron bound to tranferrin (Tf) and unbound in serum.
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